| 发明名称 |
METHOD FOR REDUCING PARAVALVULAR LEAKS WITH DECELLULARIZED TISSUE |
| 摘要 |
A method for preparing tissue, in particular pericardial tissue, in particular for use as a sealing means for a heart valve prosthesis for paravalvular leaks, characterised in that the tissue, in particular pericardial tissue, is decellularized (4), subjected to a cross-linking (6) with a glutaraldehyde-containing solution, and subjected to a shape- and a structure-stabilising step (7, 8, 9). The invention also relates to a heart valve prosthesis. |
| 申请公布号 |
US2017119928(A1) |
申请公布日期 |
2017.05.04 |
| 申请号 |
US201615291950 |
申请日期 |
2016.10.12 |
| 申请人 |
BIOTRONIK AG |
发明人 |
Rzany Alexander;Erdbruegger Wilhelm;Lehenberger Nina |
| 分类号 |
A61L27/36;A61L27/50;A61F2/24 |
主分类号 |
A61L27/36 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for preparing tissue, in particular pericardial tissue, in particular for use as a sealing means for a heart valve prosthesis for paravalvular leaks, the method comprising:
decellularizing the tissue (4); subjecting the decellularized tissue to a cross-linking solution (6) comprising glutaraldehyde; subjecting the tissue to a shape- and structure-stabilizing step (7, 8, 9), in which the tissue is exposed to a first solution (7) containing glycerol and is exposed to a second solution (8) containing polyethylene glycol; and drying the tissue after the shape- and structure-stabilizing step. |
| 地址 |
Buelach CH |
