| 发明名称 | Free base crystals | ||
| 摘要 | The present invention relates to crystals of (6aR,9aS)-5,6a,7,8,9,9a-hexahydro-5-methyl-3-(phenylamino)-2-((4-(6-fluoropyridin-2-yl)phenyl)methyl)-cyclopent[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(2H)-one, and methods of making and using such crystals. | ||
| 申请公布号 | US9630971(B2) | 申请公布日期 | 2017.04.25 |
| 申请号 | US201414900589 | 申请日期 | 2014.06.20 |
| 申请人 | INTRA-CELLULAR THERAPIES, INC. | 发明人 | Abe Takashi;Buckton Graham;Davis Robert;Hooper Mark;Li Peng;Maruyama Hideaki;Takasuga Masahiro;Wennogle Lawrence P.;Yamamoto Yuhei;Yamashita Hironori |
| 分类号 | A61K31/519;C07D487/14 | 主分类号 | A61K31/519 |
| 代理机构 | Hoxie & Associates LLC | 代理人 | Hoxie & Associates LLC |
| 主权项 | 1. A crystal of (6aR,9aS)-5,6a,7,8,9,9a-hexahydro-5-methyl-3-(phenylamino)-2-((4-(6-fluoropyridin-2-yl)phenyl)methyl)-cyclopent[4,5]imidazo[1,2-a]pyrazolo[4,3-e]pyrimidin-4(2H)-one free base (Compound A) as shown by the following chemical formula: | ||
| 地址 | New York NY US | ||