| 发明名称 |
METHODS OF TREATING CANCER |
| 摘要 |
Disclosed are methods for treating cancer such as a myeloid malignancy such as multiple myeloma in a human using EZH2 inhibitors in human populations having a translocation MMSET or a decreased level of a functional UTX protein or both. |
| 申请公布号 |
US2017105997(A1) |
申请公布日期 |
2017.04.20 |
| 申请号 |
US201515127873 |
申请日期 |
2015.03.21 |
| 申请人 |
Northwestern University ;GlaxoSmithKline Intellectual Property (No.2) Limited |
发明人 |
CREASY Caretha L.;LIGHT Jonathan;McCABE Michael;POPOVIC Relja |
| 分类号 |
A61K31/5377;A61K31/496;A61K45/06 |
主分类号 |
A61K31/5377 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of treating cancer in a human in need thereof, comprising determining at least one of the following in a sample from said human:
a. the presence of an increased level of MMSET as compared to a control; or b. the presence or absence of a decreased level of a functional UTX protein as compared to a control; and administering to said human an effective amount of an EZH2 inhibitor or pharmaceutically acceptable salt thereof if there is an increased level of MMSET as compared to a control or there is a decreased level of a functional UTX protein as compared to a control, or both. |
| 地址 |
Evanston IL US |
