发明名称 |
ANTI-CANCER EFFECTS OF JAK2 INHIBITORS IN COMBINATION WITH THALIDOMIDE DERIVATIVES AND GLUCOCORTICOIDS |
摘要 |
The present invention provides methods of treatment for hematological malignancies involving synergistic combination of a JAK2 inhibitor and a glucocorticoid or a JAK2 inhibitor, thalidomide or thalidomide derivative, and a glucocorticoid. The compositions and methods provide an unexpected efficacy in the treatment for hematological disorders. The hematological disorders treated by the current invention include multiple myeloma, and may also include hematological disorders that are refractory to prior cancer treatments, or a relapsed hematologic disorder. |
申请公布号 |
US2017106003(A1) |
申请公布日期 |
2017.04.20 |
申请号 |
US201515314434 |
申请日期 |
2015.05.28 |
申请人 |
Institute for Myeloma & Bone Cancer Research |
发明人 |
BERENSON James R. |
分类号 |
A61K31/573;A61K31/519;A61K9/00;A61K31/454 |
主分类号 |
A61K31/573 |
代理机构 |
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代理人 |
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主权项 |
1. A method of treating or preventing a hematological malignancy in a subject comprising administering to the subject a JAK2 inhibitor, and a glucocorticoid. |
地址 |
West Hollywood CA US |