Molecular analysis using micro electro-mechanical sensor devices

摘要

Analysis instruments and sensors, particularly micro-electro mechanical sensor (MEMS) devices, for molecular analysis of chemicals and other materials, including, for example, polymers, drugs, nanomaterials, biological samples including proteins, and environmental samples including water suspected of contamination, and the like in vapor, liquid, and/or solid form.

主权项

1. A sensor device for at least one of differential scanning calorimetry and differential thermal analysis of an analyte, the sensor device comprising:
an array comprising a plurality of sensor cells arranged in at least one row and in at least one column, each sensor cell configured to receive analyte for analysis thereof, each sensor cell comprising:
a heating element configured to heat at least one of the sensor cell or the analyte; anda temperature sensor element configured to sense a temperature response of at least one of the sensor cell and the analyte; and a controller configured to:
drive the heating element of at least one sensor cell according to a first temperature ramp cycle while analyte is present on the at least one sensor cell;drive the heating element of the at least one sensor cell according to a second temperature ramp cycle to clean the at least one sensor cell; anddrive the heating element of the cleaned at least one sensor cell according to a third temperature ramp cycle to obtain reference temperature data; and a processor configured to determine a difference between an output signal from the temperature sensor of the at least one sensor cell during the first temperature ramp cycle and an output signal from the temperature sensor of the at least one sensor cell during the third temperature ramp cycle.