Hatching fluid enzymes and uses thereof

摘要

The present invention relates to various polypeptides from fish hatching fluid, their encoding nucleic acid sequences, pharmaceutical compositions comprising said polypeptides and nucleic acid molecules and their use in various medical and cosmetic applications to the skin, particularly for moisturizing skin and/or for exfoliation of the horny layer of the skin for treating or preventing skin disorders or conditions in an animal.

主权项

1. A method of treating a condition or disorder of the skin of an animal, said method comprising administering topically a pharmaceutical or cosmetic composition to said animal wherein:
said pharmaceutical or cosmetic composition comprises:
(i) an isolated polypeptide having metalloproteinase activity comprising an amino acid sequence as set forth in SEQ ID NO: 1; or(ii) an isolated polypeptide having metalloproteinase activity comprising an amino acid sequence which is at least 90% identical to a sequence as set forth in SEQ ID NO: 1; or(iii) an isolated polypeptide having metalloproteinase activity comprising a portion of an amino acid sequence as set forth in SEQ ID NO: 1, wherein said portion comprises at least 150 amino acids; or(iv) an isolated polypeptide having metalloproteinase activity comprising a portion of an amino acid sequence which is at least 90% identical to a comparable region of an amino acid sequence as set forth in SEQ ID NO: 1 and comprises at least 150 amino acids; and one or more pharmaceutically or cosmetically acceptable excipients and/or diluents, and wherein the condition or disorder of the skin of the animal selected from the group consisting of eczema, contact dermatitis, psoriasis, ichthyosis, acne, calluses, corns, warts, a benign hyperproliferative disorder and a pigmentation disorder.