Siglec-15 antibodies in treating bone loss-related disease

摘要

Novel antibodies and antigen binding fragments that specifically binds to Siglec-15 are described herein. In some embodiments, the antibodies or antigen binding fragments may block the biological activity of Siglec-15 and are useful in composition for the treatment of bone loss, more particularly in bone diseases that have increased cell surface expression of Siglec-15, such as conditions where there is an increase in the bone degradative activity of osteoclasts. The invention also relates to cells expressing the antibodies or antigen binding fragments such as monoclonal, humanized or chimeric antibodies. Additionally, methods of detecting and treating bone loss, bone-related diseases or cancer using the antibodies and fragments are also disclosed.

主权项

1. A nucleic acid comprising a sequence encoding a light chain variable domain and/or heavy chain variable domain of an antibody or antigen binding fragment thereof that specifically binds to Siglec-15 (SEQ ID NO.:2), said light chain variable domain comprising complementarity determining regions having the amino acid sequence set forth in SEQ ID NO.:81, SEQ ID NO.:82 and SEQ ID NO.:83 and said heavy chain variable domain comprising complementarity determining regions having the amino acid sequence set forth in SEQ ID NO.:84, SEQ ID NO.:85 and SEQ ID NO.: 86.