Oral pharmaceutical dosage forms

摘要

Controlled release oral dosage forms suitable for administration of methylphenidate are provided. Abuse-resistant controlled release oral dosage forms suitable for administration of methylphenidate are also provided. Methods of treating ADD and ADHD using the oral dosage forms are also provided.

主权项

1. An oral controlled release dosage form comprising a formulation comprising:
methylphenidate at about 5 to about 30 wt % relative to the total weight of the formulation; sucrose acetate isobutyrate (SAIB) at about 30 to about 45 wt % relative to the total weight of the formulation; a rheology modifier at about 2 to about 15 wt % relative to the total weight of the formulation; a network former at about 2 to about 10 wt % relative to the total weight of the formulation; a solvent at about 15 to about 40 wt % relative to the total weight of the formulation; a viscosity enhancing agent at about 0.1 to about 2 wt % relative to the total weight of the formulation; and a saturated polyglycolized glyceride at about 0.01 to about 5 wt % relative to the total weight of the formulation.