发明名称 |
Heptamer-type small guide nucleic acids inducing apoptosis of human leukemia cells |
摘要 |
There is provided a heptamer-type small guide nucleic acid that comprises any of the 7-base sequences of SEQ ID NOS: 1 to 15, and induces apoptosis of human leukemia cells. A leukemia therapeutic agent containing the heptamer-type small guide nucleic acid as an active ingredient is also provided. The novel heptamer-type sg nucleic acid can induce apoptosis of human leukemia cells. |
申请公布号 |
US9617538(B2) |
申请公布日期 |
2017.04.11 |
申请号 |
US201214241580 |
申请日期 |
2012.08.24 |
申请人 |
NIIGATA UNIVERSITY OF PHARMACY AND APPLIED LIFE SCIENCE;NIIGATA UNIVERSITY |
发明人 |
Nashimoto Masayuki;Takahashi Masuhiro;Narita Miwako;Yoshida Tetsuo;Miyazawa Tatsuya |
分类号 |
C07H21/02;C12N15/113;A61K31/7105 |
主分类号 |
C07H21/02 |
代理机构 |
Wenderoth, Lind & Ponack, L.L.P. |
代理人 |
Wenderoth, Lind & Ponack, L.L.P. |
主权项 |
1. A leukemia therapeutic agent, which comprises one or more of a small guide RNA consisting of a sequence selected from SEQ ID NOS: 1, 2, 3, 4, 7, 8, 10, 11, 12, 13 or 15 as an active ingredient,
wherein one or more of the small guide RNA is phosphorylated at the 5′ and 3′ ends, and is 2′-O-methylated. |
地址 |
Niigata JP |