| 主权项 |
1. A compound having formula (I): where X, Y and Z are H, F, or Cl; R1 is OR, where R is hydrogen or a group selected from straight or branched C1-C6 alkyl, C2-C6 alkenyl, C2-C6 alkynyl, C3-C6 cycloalkyl, heterocyclyl, CF3, CCl3, and aryl in positions 2, 3 or 4; R2 is OH, alkoxy, aryloxy, CH2OR (where R is H, linear or branched aryl, cycloalkyl or alkyl), CH2NR′R″ (where R′ and R″ are independently H, linear or branched aryl, cycloalkyl or alkyl), CHO, OCOW (where W is linear or branched aryl or alkyl or C-(halogen)3), CONR′R″ (where R′ and R″ independently are H, alkyl, cycloalkyl or aryl), COOR (where R is H, alkyl, cycloalkyl or aryl), CH2NHSO2R (where R is H, alkyl, cycloalkyl or aryl), Cl, Br, F, substituted or unsubstituted CH2—N-benzimidazole (substituted by a group selected from F, Cl, straight or branched C1-C6 alkyl or OC1—C6 alkyl), CONHNR′R″ (where R′ and R″ independently are H, alkyl, cycloalkyl or aryl), CONHNR′R″ (where R′ and R″ independently are H, alkyl, cycloalkyl and or aryl), NRCOOR′ (where R and R′ are independently H, alkyl, cycloalkyl or aryl), NH2, NR′R″ (where R′ and R″ independently are alkyl, cycloalkyl or aryl), NHCOR (where R is H, alkyl, cycloalkyl or aryl), nitro, OCH2CH2-heterocyclyl, OCOR (where R is H, alkyl, cycloalkyl or aryl), OCONR′R″ (where R′ and R″ are independently H, alkyl, cycloalkyl or aryl), OCOOR (where R is H, alkyl, cycloalkyl or aryl), NHCOOCH2C-halo3, NRCONR′R″ (where R, R′ and R″ independently are H, alkyl, cycloalkyl or aryl), NHSO2R (where R is H, alkyl, cycloalkyl or aryl), NHSO2NR′R″ (where R′ and R″ independently are H, alkyl, cycloalkyl or aryl), and R3 is OH, alkoxy, aryloxy, Cl, F, morpholino, N-4-methylpiperazino, NR′R″ (where R′ and R″ independently are H or alkyl), NHCOR (where R is H, alkyl, cycloalkyl or aryl), and CONR′R″ (where R′ and R″ independently are H, alkyl, cycloalkyl or aryl). |
