| 发明名称 | Taxane analogs for the treatment of brain cancer | ||
| 摘要 | Provided herein are compounds and methods for the treatment of brain cancer in a mammal, wherein the method comprises the administration to the mammal a compound that stabilizes tubulin dimers or microtubles at G2-M interface during mitosis but is not a substrate for MDR protein. In particular, the present application relates to the use of an orally effective abeo-taxane, alone or in combination with temozolomide or bevacizumab, for the treatment of brain cancer. | ||
| 申请公布号 | US9616043(B2) | 申请公布日期 | 2017.04.11 |
| 申请号 | US201514851255 | 申请日期 | 2015.09.11 |
| 申请人 | Tapestry Pharmaceuticals, Inc. | 发明人 | McChesney James D.;Tapolsky Gilles;Emerson David L.;Marshall John;Kurman Michael;Modiano Manuel |
| 分类号 | A61K31/357;A61K45/06;A61K31/337;A61K31/4188;C07D493/04;A61K31/495;A61K39/395 | 主分类号 | A61K31/357 |
| 代理机构 | Morgan, Lewis & Bockius, LLP | 代理人 | Morgan, Lewis & Bockius, LLP |
| 主权项 | 1. A pharmaceutical composition comprising a compound having a structure of formula (1): | ||
| 地址 | Atlanta GA US | ||