The invention is directed to methods and metric suitable for use in modulating the expression of a polypeptide encoded by a nucleic acid sequence. In certain aspects, the invention also relates to methods for introducing modifications in a polypeptide, for example through substitution of one or more nucleic acids in an untranslated sequence or in a coding sequence of a nucleic acid sequence encoding a polypeptide to increase the expression of the polypeptide.
申请公布号
EP3149176(A1)
申请公布日期
2017.04.05
申请号
EP20150799855
申请日期
2015.06.01
申请人
The Trustees of Columbia University in the City of New York;Hunt, John, Francis, III;Aalberts, Daniel;Boel, Gregory, P.
发明人
HUNT, John, Francis, III;AALBERTS, Daniel;BOEL, Gregory, P.
