发明名称 |
Sustained drug delivery implant |
摘要 |
Biocompatible intraocular implants may include a brimonidine free base and a biodegradable polymer associated with the brimonidine free base to facilitate the release of the brimonidine free base into an eye with the polymer matrix lasts a period of time of not more than twice the drug release duration, but more than the drug release duration. |
申请公布号 |
US9610246(B2) |
申请公布日期 |
2017.04.04 |
申请号 |
US201414218324 |
申请日期 |
2014.03.18 |
申请人 |
Allergan, Inc. |
发明人 |
Shiah Jane-Guo;Pujara Chetan |
分类号 |
A61K9/00;A61K31/498;A61F9/00 |
主分类号 |
A61K9/00 |
代理机构 |
|
代理人 |
Wine Laura L. |
主权项 |
1. A solid intraocular implant for the treatment of a posterior ocular condition in a human patient, the solid intraocular implant consisting of:
a brimonidine free base in an amount of about 40% by weight to about 60% by weight of the implant, based on the total weight of the implant; and a biodegradable polymer matrix comprising an acid end-capped poly (D, L-lactide) polymer and a 75:25 poly (D,L-lactide-co-glycolide) polymer; wherein the weight ratio of the acid end-capped poly (D, L-lactide) polymer to the 75:25 poly (D,L-lactide-co-glycolide) polymer is 1:1; and wherein the implant has a brimonidine free base delivery duration of two months to four months when placed in the eye of a human; and wherein the implant has a polymer matrix degradation time in the range of about three months to about six months when placed in the eye of a human. |
地址 |
Irvine CA US |