Use of a PCV2 immunogenic composition for lessening clinical symptoms in pigs

摘要

The present invention relates to the use of an immunogenic composition that comprises a porcine circovirus type 2 (PCV2) antigen for treatment of several clinical manifestations (diseases). Preferably, the clinical manifestations are associated with a PCV2 infection. Preferably, they include lymphadenopathy, lymphoid depletion and/or multinucleated/giant histiocytes. Moreover, the clinical symptoms include lymphadenopathy in combination with one or a multiple of the following symptoms in pigs: (1) interstitial pneumonia with interlobular edema, (2) cutaneous pallor or icterus, (3) mottled atrophic livers, (4) gastric ulcers, (5) nephritis and (6) reproductive disorders, e.g. abortion, stillbirths, mummies, etc. Furthermore the clinical symptoms include Pia like lesions, normally known to be associated with Lawsonia intracellularis infections.

主权项

1. A method for preventing and/or reducing one or more symptoms of PCV2 infection comprising administering to a piglet or group of piglets 2-6 weeks of age a single efficacious dose of an immunogenic composition comprising PCV2 ORF2 protein and at least one additional component selected from the group consisting of a veterinary-acceptable carrier, a pharmaceutical-acceptable carrier, an adjuvant, cell culture supernatant, a preservative, a stabilizing agent, a viral vector, and an immunomodulatory agent.