| 主权项 |
1. A method of increasing a deacetylase activity of SIRT5, wherein the method comprises contacting SIRT5 with an agent that binds SIRT5 and reduces the Km of SIRT5 for a substrate, thereby increasing the deacetylase activity of SIRT5,
wherein the agent is a compound of the formula (I): wherein R1 and R2 are independently selected from the group consisting of hydrogen, optionally substituted acyl, optionally substituted acyloxy, trialkylsilyl, optionally substituted alkyl, optionally substituted alkylaryl, phosphate, diphosphate, and triphosphate, R3 is hydrogen and R4 is hydroxyl, R3 and R4 are fluoro, or R3 is hydrogen and R4 is chloro, R5, R7, R8, and R9 are independently selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted arylalkyl, F, Cl, Br, I, CF3, optionally substituted alkoxy, optionally substituted aryl, NO2, optionally substituted alkylthio, optionally substituted amino, optionally substituted acylamino, optionally substituted arylamino, optionally substituted acylthio, optionally substituted acyl, optionally substituted acyloxy, hydroxy, mercapto, and optionally substituted thioamido, or any of R5 and R6 taken together, R6 and R7 taken together, R7 and R8 taken together, or R8 and R9 taken together, form a 5- or 6-membered saturated or unsaturated ring, R6 is COR10 or B(OR11)2, R10 is selected from the group consisting of hydrogen, hydroxy, alkoxy, and aryloxy, and R11 is hydrogen or C1-C6 alkyl. |
