PEPTIDE ANTAGONIST OF LL-37

摘要

This disclosure is related to the peptide antagonist of LL-37, an antimicrobial peptide that has multiple functions in both innate and adaptive immune response. Specifically, the identified peptide antagonists of LL-37 provide inhibition to detrimental autoimmune inflammatory response, whereas at the same time retain LL-37's antibacterial activity.

主权项

1. A composition of LL-37 antagonist, comprising a peptide that inhibits autoimmune inflammatory responses induced by bacterial endotoxins, double-stranded RNAs or single-strand DNAs but retains antibacterial activity, wherein said peptide binds to LL-37 and/or endotoxins, but fails to bind double-stranded RNA or single-stranded DNA.