Syringes for prefilled and fill-at-use mixing and drug delivery

摘要

Mixing syringes including a valve mechanism are configured and configurable to enable one or more substances to be prefilled into the syringe. The valve mechanism may be an aspect of a distal seal assembly. Actuation of the valve mechanism permits opening of a fluid passage for the mixing of one or more substances, and the resulting mixed substance can be delivered by the syringe, for example, for administration of a pharmaceutical to a subject.

主权项

1. A prefillable mixing syringe for administration of at least one substance comprising
a syringe housing; a distal seal assembly axially displaceably disposed within the housing, wherein the position of the distal seal assembly defines a mutable distal chamber and a mutable proximal chamber within the housing; the distal seal assembly further comprising a valve that regulates a fluid passage between the proximal and distal chambers; a proximal seal; a connector configured to connect irreversibly the proximal seal and the distal seal assembly, wherein the connected proximal seal and distal seal assembly translate axially together within the housing; and a plunger rod positioned coaxially within the syringe housing and engaged with the valve, wherein the plunger rod actuates the valve.