IDENTIFICATION OF NOVEL DIAGNOSTICS AND THERAPEUTICS BY MODULATING RHOH

摘要

The disclosure relates to identifying novel therapeutic targets and/or diagnostic and/or prognostic markers by correcting abnormal RhoH expression in a hematopoietic cell.

主权项

1. A method of identifying a hematopoietic disorder-associated molecule in a hematopoietic cell, the method comprises:
identifying a hematopoietic cell having abnormal RhoH level, restoring RhoH level in the cell to a control level, and measuring a level of a molecule in the cell before and after restoring the level of RhoH in the cell to the control level, wherein a decrease in the level of the molecule in the cell after restoring the RhoH level in the cell to the control level indicates that the molecule is a hematopoietic disorder-associated molecule.