Enamel protectant and repair toothpaste treatments

摘要

Substantially aqueous-free, enamel protectant and enamel repair toothpaste treatments containing: stannous fluoride, calcium and a substantivity agent comprising: an emulsion of polydimethylsiloxane in a nonionic surfactant, wherein: (a) substantivity of said stannous fluoride and calcium into biofilm present on enamel is enhanced through calcium binding shifting from bidentate to monodentate in the presence of stannous fluoride; and (b) said toothpaste treatments indicate substantially improved, enamel protectant factor (EPF) and enamel repair factor (ERF) values compared to fluoride brushing treatments with comparable or higher fluoride levels.

主权项

1. An aqueous-free, enamel protectant and enamel repair, toothpaste treatments containing: stannous fluoride and calcium in a substantivity agent selected from emulsions of polymethylsiloxanes in nonionic poloxamer surfactants, wherein:
(a) Substantivity of said stannous fluoride and calcium into biofilm present on enamel is enhanced through a shift in calcium binding from bidentate to monodentate in the presence of stannous fluoride; (b) EPF and ERF values of at least 2.5 and 200, respectively, are achieved with periodic administration of said toothpastes onto enamel surfaces with biofilm present; (c) wherein the stannous fluoride is present in an amount of 400-1100 ppm; (d) wherein the composition has a pH of 3-5.8; (e) wherein the calcium content is 0.5-5.0%; (f) wherein the calcium is limited to one or more of calcium fumarate, calcium sulfate, calcium gluconate, and mixed sodium and calcium salts of methyl/vinyl/ether/maleic copolymers thereof; and (g) wherein said nonionic poloxamer is selected from solid and liquid, nonionic poloxamers and combinations thereof.