| 发明名称 | Aldehyde-selective wacker-type oxidation of unbiased alkenes | ||
| 摘要 | This disclosure is directed to methods of preparing organic aldehydes, each method comprising contacting a terminal olefin with an oxidizing mixture comprising: (a) a dichloro-palladium complex;(b) a copper complex;(c) a source of nitrite; under aerobic reaction conditions sufficient to convert at least a portion of the terminal olefin to an aldehyde. | ||
| 申请公布号 | US9586883(B2) | 申请公布日期 | 2017.03.07 |
| 申请号 | US201414255049 | 申请日期 | 2014.04.17 |
| 申请人 | California Institute of Technology | 发明人 | Wickens Zachary K.;Morandi Bill;Grubbs Robert H.;Skakuj Kacper;Bronner Sarah M. |
| 分类号 | C07C45/34;C07C249/04;C07C253/00;C07C201/12;C07C205/44;C07C209/60;C07C213/00;C07C227/08;C07C51/373;C07C59/235;C07C211/48;C07C217/48;C07D301/22 | 主分类号 | C07C45/34 |
| 代理机构 | Baker & Hostetler LLP | 代理人 | Baker & Hostetler LLP |
| 主权项 | 1. A method comprising contacting a terminal olefin with a Wacker-type oxidation catalyst system mixture comprising: (a) a dichloro-bis(nitrile) palladium (II) complex; and (b) copper chloride, either as CuCl or CuCl2;said Wacker-type oxidation catalyst system mixture further comprising (c) an inorganic nitrite salt;said contacting done in the presence of a tertiary alcohol under aerobic reaction conditions sufficient to convert at least a portion of the terminal olefin to an aldehyde, such that the selectivity for aldehyde is at least 50%. | ||
| 地址 | Pasadena CA US | ||