| 发明名称 | Compositions and methods comprising glycyl-tRNA synthetases having non-canonical biological activities | ||
| 摘要 | Isolated glycyl-tRNA synthetase polypeptides and polynucleotides having non-canonical biological activities are provided, as well as compositions and methods related thereto. | ||
| 申请公布号 | US9585946(B2) | 申请公布日期 | 2017.03.07 |
| 申请号 | US201514844666 | 申请日期 | 2015.09.03 |
| 申请人 | aTyr Pharma, Inc. | 发明人 | Greene Leslie Ann;Adams Ryan Andrew;Hong Fei;Zhao Ji;Armour Eva Rebecka Stephanie;Piehl Kristi Helen |
| 分类号 | C12N9/00;C12N15/00;C12P21/06;C12P21/04;A61K38/43;A61K38/53;C12N9/96;C07K1/14;C12N15/10 | 主分类号 | C12N9/00 |
| 代理机构 | Cooley LLP | 代理人 | Cooley LLP |
| 主权项 | 1. A pharmaceutical composition, comprising a pharmaceutically-acceptable carrier and an isolated RNA polynucleotide having at least one modified nucleotide, wherein the isolated RNA polynucleotide encodes a glycyl-tRNA synthetase (GRS) polypeptide that is up to about 500 amino acids in length and comprises amino acid residues 367-438 of SEQ ID NO:1, or a GRS variant that comprises a sequence at least 95% identical to residues 367-438 of SEQ ID NO:1. | ||
| 地址 | San Diego CA US | ||