| 发明名称 | Methods and compositions for modulating Tau levels | ||
| 摘要 | Methods and agents for reducing a level of an acetylated Tau polypeptide in a cell are provided. Methods for treating a tauopathy in an individual are also provided. Also provided is a method for diagnosing a cognitive impairment disorder in an individual. Methods for identifying an agent suitable for treating a tauopathy are also provided. | ||
| 申请公布号 | US9585907(B2) | 申请公布日期 | 2017.03.07 |
| 申请号 | US201514697156 | 申请日期 | 2015.04.27 |
| 申请人 | The J. David Gladstone Institutes | 发明人 | Gan Li |
| 分类号 | A61K31/55;G01N33/542;C12N5/02;A61K31/713;A61K31/551;A61K38/50;G01N33/68;A61K9/00;A61K31/4155;G01N33/556 | 主分类号 | A61K31/55 |
| 代理机构 | Bozicevic, Field & Francis LLP | 代理人 | Rubin Michael B.;Bozicevic, Field & Francis LLP |
| 主权项 | 1. A method for treating a tauopathy in an individual, the method comprising administering to the individual an effective amount of a p300 inhibitor that reduces the level of acetylated Tau in a neuron or a glial cell in the individual. | ||
| 地址 | San Francisco CA US | ||