USE OF AROMATIC-CATIONIC PEPTIDES TO TREAT CHOLESTEROL-INDUCED MITOCHONDRIAL DYSFUNCTION

摘要

The present disclosure provides aromatic-cationic peptide compositions and methods of using the same. The methods comprise use of the peptides in inhibiting cholesterol-induced cytochrome c peroxidase activity, promoting reduction of cytochrome c, and inhibition of cardiolipin peroxidation to treat, prevent or ameliorate cholesterol-induced mitochondrial dysfunction.

主权项

1. A method for treating a subject suffering from a disease characterized by cholesterol-induced mitochondrial dysfunction, comprising: administering a therapeutically effective amount of an aromatic-cationic peptide or a pharmaceutically acceptable salt thereof to the subject.