| 发明名称 |
CARBOXYLIC ACID DERIVATIVES AND USE THEREOF IN THE PREPARATION OF PRODRUGS |
| 摘要 |
The present invention discloses a class of carboxylic acid derivatives and use thereof in preparation of prodrugs. The carboxylic acid derivatives have the general formula (I), wherein R1 is H or alkyl; X is H or F; Y is F or fluoroalkyl; n is 0, 1, 2, 3, 4, 5, or 6; W is W1 or W2; W1 is NR2R3, NR2R3.A,;;R2 and R3 are each independently H, alkyl, cycloalkyl, or a protecting group for amino; m is 0, 1, 2, or 3; A is an acid; W2 is COOR4, OPO(OR4)2, or PO(OR4)2; R4 is H, or a protecting group for carboxyl or hydroxyl in phosphoric acid.; |
| 申请公布号 |
US2017057939(A1) |
申请公布日期 |
2017.03.02 |
| 申请号 |
US201515119587 |
申请日期 |
2015.02.16 |
| 申请人 |
Li Qingeng |
发明人 |
Li Qingeng;Wang Tao;Chen Gang;Wang Yuanzhong;Mao Wei;Wu Tong;Zeng Lingguo |
| 分类号 |
C07D305/14;C07D405/12 |
主分类号 |
C07D305/14 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A carboxylic acid derivative of general formula (I), (II) or (III): wherein, R1 is H or alkyl; X is H or F; Y is F or alkyl substituted with one or more F; n is 0, 1, 2, 3, 4, 5 or 6; W is W1 or W2; W1 is NR2R3, NR2R3.A, R2, R3 are each independently H, alkyl, cycloalkyl, or a protecting group for amino; m is 0, 1, 2 or 3; A is an acid; W2 is COOR4, OPO(OR4)2 or PO(OR4)2; R4 is H, or a protecting group for carboxyl or hydroxyl in phosphoric acid; M is a metal ion; q is the charge number of M; and G is Cl, Br or benzenesulfonyloxy optionally substituted with alkyl. |
| 地址 |
Chongqing CN |
