发明名称 |
METHOD FOR PRODUCING -HALO-TETRAACYL GLUCOSE |
摘要 |
There is provided an efficient and excellent preparation method of an ±-halo-tetraacyl-glucose which is suitable for industrial preparation, which comprises reacting D-glucose or lower alkyl D-glucoside with a reactive derivative of a carboxylic acid and a metal halide to prepare the ±-halo-tetraacyl-glucose represented by the formula (III):
wherein R represents an optionally substituted lower alkyl group or an optionally substituted aryl group, and X represents a halogen atom,
in one step, and the resulting ±-halo-tetraacyl-glucose (III) can be converted into a compound of the formula (I) or a salt thereof by subjecting to a conventional method. |
申请公布号 |
EP2963048(A4) |
申请公布日期 |
2017.03.01 |
申请号 |
EP20140756953 |
申请日期 |
2014.02.25 |
申请人 |
Mitsubishi Tanabe Pharma Corporation |
发明人 |
UEDA, Keita;HATSUDA, Masanori;HYODO, Isao;TANIMOTO, Kouichi |
分类号 |
C07H5/02;A61K31/381;A61P3/10;C07B61/00;C07D409/10;C07H13/02;C07H13/04;C07H13/08 |
主分类号 |
C07H5/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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