| 发明名称 |
OPHTHALMIC FORMULATIONS |
| 摘要 |
The present invention relates to an ophthalmic formulation which comprises a fine particle of Compound A in an aqueous suspension and a manufacturing process thereof. More specifically, the present invention relates to a topically applied ophthalmic aqueous suspension which is obtainable by suspending fine particles of Compound A in an aqueous vehicle containing a surfactant and boric acid. The invention also provides processes for making the ophthalmic formulations and to methods of use thereof. |
| 申请公布号 |
US2017049799(A1) |
申请公布日期 |
2017.02.23 |
| 申请号 |
US201615345734 |
申请日期 |
2016.11.08 |
| 申请人 |
Inotek Pharmaceuticals Corporation |
发明人 |
MCVICAR William K.;TAKRURI Harun |
| 分类号 |
A61K31/7076;A61K47/02;A61K31/5575;A61K47/26;A61K45/06;A61K9/00;A61K47/38 |
主分类号 |
A61K31/7076 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of reducing intraocular pressure comprising the step of: topically applying an effective amount of an ophthalmic formulation to an affected eye of a patient, wherein the formulation comprises:
(a) an aqueous suspension of micronized Compound A from 0.1 to 5.0% (w/v) in the formulation; (b) a surfactant; (c) boric acid from about 0.05 to about 2.0% (w/v); and (d) a buffering agent that maintains the pH from about 6.0 to about 7.0. |
| 地址 |
Lexington MA US |
