PROGRAMMABLE MIP CATCH AND RELEASE TECHNOLOGY

摘要

Programmable molecular imprinted polymers (MIPs) that have modified binding site kinetics for target imprintable entities (TIEs) that operate to control the adsorption, binding, release and equilibrium distribution of related materials into and out of the MIPs, which are useful for the controlled adsorption, controlled release and control of concentrations of such materials in media including gases, liquids, fluids, biological systems, solutions and other environments. When a collective plurality of the MIPs with modified binding site kinetics are combined, the resulting MIP systems can be tailored to exhibit pseudo zero- and first-order kinetics, as well as higher kinetic profiles, and when further combined with time-delay functionality, can be tailored to exhibit delayed uptake and release, ramped uptake and release of materials, step functions, polynomial, geometric, exponential and other unique kinetic profiles of material exchange between the novel MIPs and a fluid media that are not readily achievable by other means.

主权项

1. A polymeric matrix comprising:
a plurality of binding sites within a molecularly imprinted polymer (MIP) that exhibit at least one average associative binding constant (km) with respect to a selected material (m); wherein the magnitude of said average associative binding constant is significantly different than that of the average equilibrium associative binding constant exhibited by said polymer matrix for a reference target imprinted entity (TIE) used as the template forming entity in the formation of said plurality of binding sites within said MIP; and wherein said plurality of binding sites operate to enable the controlled capture and the controlled release of said selected material, and combinations thereof, when in contact with a fluid media.