COMPOUND LIBRARY PREPARATION PROCESS BASED ON EXCHANGE REACTION BETWEEN DIFERENTLY SUBSTITUTED DIOXABOROLANES OR DIOXABORINANES

摘要

The present invention relates to the preparation of a compound library comprising the following steps: • i. Having available at least two different compounds each comprising at least a dioxaborolane or dioxaborinane ring. In said compounds: • -the boron of the dioxaborolane or dioxaborinane ring is directly linked to a carbon atom of a hydrocarbon radical; • -at least one carbon atom of the dioxaborolane or dioxaborinane ring is monosubstituted, the other carbon atoms are non- substituted or monosubstituted; • -in at least two compounds, the hydrocarbon radicals linked to the boron are different; • - in at least two compounds, either the dioxaborolane or dioxaborinane ring carbon atoms are differently substituted and/ or the size varies. • ii. Reacting the compounds of step (i.) and forming, by a boronic ester metathesis reaction, the library comprising at least four different compounds. The present invention also relates to a compound library. Illustrative for the present invention is the following figure: