Antibodies against tissue factor pathway inhibitor

摘要

The invention relates to antibodies that specifically bind to tissue factor pathway inhibitor (TFPI) and that reduce the clotting time of blood. Such antibodies have utility in the treatment of subjects with a coagulopathy.

主权项

1. A monoclonal antibody that specifically binds the K2 domain (Kunitz domain 2) of TFPI, wherein said antibody specifically binds an epitope comprising residues E10, E11, D12, P13, R17, Y19, T21, Y23, F24, N26, Q28, Q31, C32, E33, R34, K36, and L50 of SEQ ID NO: 2.