p16 protein variant and use thereof for preventing or treating cancer

摘要

A p16 protein variant; a polynucleotide encoding the p16 protein variant; a method for preparing the p16 protein variant; a pharmaceutical composition comprising the p16 protein variant; a method for preventing and/or treating cancer comprising administering the p16 protein variant to a subject; and use of the p16 protein variant in the prophylaxis and/or therapy of cancer.

主权项

1. A recombinant or synthetic p16 protein variant comprising a p16 protein in which at least one hydrophobic amino acid residue that is exposed on the tertiary structure of the p16 protein in aqueous solution is substituted with a hydrophilic amino acid, wherein the hydrophobic amino acid is leucine (L), cysteine (C), valine (V), phenyl alanine (F), tryptophan (W), isoleucine (I), proline (P), methionine (M), or a combination thereof; and the hydrophilic amino acid is lysine (K), aspartic acid (D), glutamic acid (E), glutamine (Q), asparagine (N), serine (S), alanine (A), threonine (T), arginine (R), or a combination thereof.