发明名称 |
Antibodies against factor XII and uses thereof |
摘要 |
Provided are antibodies that selectively bind to and inhibit activation of coagulation factor XII. Methods of treatment employing these antibodies are described herein. |
申请公布号 |
US9574013(B2) |
申请公布日期 |
2017.02.21 |
申请号 |
US201314649972 |
申请日期 |
2013.12.06 |
申请人 |
VANDERBILT UNIVERSITY;ARONORA, INC.;OREGON HEALTH & SCIENCE UNIVERSITY |
发明人 |
Gruber Andras;Gailani David;Leung Philberta;Matafonov Anton |
分类号 |
A61K39/395;C07K16/36;C07K16/40;A61K39/00 |
主分类号 |
A61K39/395 |
代理机构 |
Parker Highlander, PLLC |
代理人 |
Parker Highlander, PLLC |
主权项 |
1. An antibody which binds factor XII comprising:
(a) a light chain comprising light chain CDRs represented by SEQ ID NOS: 1, 2 and 3; and (b) a heavy chain comprising heavy chain CDRs represented by SEQ ID NOS: 4, 5 and 6. |
地址 |
Nashville TN US |