| 发明名称 | Methods and compositions for modulating apolipoprotein (a) expression | ||
| 摘要 | Disclosed herein are antisense compounds and methods for decreasing apo(a) to treat, prevent, or ameliorate diseases, disorders or conditions related to apo(a) or Lp(a). Certain diseases, disorders or conditions related to apo(a) or Lp(a) include inflammatory, cardiovascular and/or metabolic diseases, disorders or conditions. The antisense compounds disclosed herein can be used to treat such diseases, disorders or conditions in an individual in need thereof. | ||
| 申请公布号 | US9574193(B2) | 申请公布日期 | 2017.02.21 |
| 申请号 | US201414552436 | 申请日期 | 2014.11.24 |
| 申请人 | Ionis Pharmaceuticals, Inc. | 发明人 | Crooke Rosanne M.;Graham Mark J.;Freier Susan M.;Lim Marc;Dibble Andrew |
| 分类号 | C12N15/113 | 主分类号 | C12N15/113 |
| 代理机构 | Ionis Pharmaceuticals, Inc. Patent Dept. | 代理人 | Ionis Pharmaceuticals, Inc. Patent Dept. |
| 主权项 | 1. A method of lowering apo(a) and/or Lp(a) levels in a subject, comprising: administering to said subject a compound comprising a modified oligonucleotide, wherein: the modified oligonucleotide consists of 14 to 25 linked nucleosides and comprises a nucleobase sequence comprising a portion of at least 14 contiguous nucleobases complementary to an equal length portion of nucleobases 3900 to 3923 of SEQ ID NO: 1, wherein the nucleobase sequence of the modified oligonucleotide is at least 95% complementary to SEQ ID NO: 1, or a salt thereof, whereby apo(a) and/or Lp(a) levels are reduced in the animal subject. | ||
| 地址 | Carlsbad CA US | ||