METHODS OF DIAGNOSING AND TREATING aCML and CNL

摘要

Disclosed herein are methods and kits used in treating a cancer characterized by aberrant activity of CSF3R. These methods involve detecting a mutation in exon 14 of CSF3R such as a mutation of T615 or T618 and treating the subject with a JAK inhibitor and/or detecting a mutation in exon 17 of CSF3R and treating with dasatinib or tyrosine kinase inhibitor with one or more targets in common with dasatinib.

主权项

1. A method of treating a chronic neutrophilic leukemia or atypical chronic myeloid leukemia in a subject, the method comprising:
obtaining a sample from the subject, where the sample comprises one or more leukemia cells; amplifying a nucleic acid fragment comprising SEQ. ID NO: 8 from the sample; and administering a pharmaceutical composition comprising ruxolitinib to the subject, provided that the amplified nucleic acid fragment comprises a mutation that corresponds to a mutation of T618 in SEQ ID NO: 1, thereby treating the chronic neutrophilic leukemia or atypical chronic myeloid leukemia.