| 摘要 |
Aurones anticancer compound drug intermediates 2,4,6-hydroxyacetophenone synthesis method, comprising the following steps: equipped with a stirrer, a thermometer, a reflux condenser, a reaction vessel, 0.21mol m-trihydroxybenzene, 0.41mol 4-chloro -phenethylamine, 200ml butyl acetate, 0.02-0.025mol cuprous bromide, reducing the solution temperature to 3--5 C, controlling the stirring speed at 100-120rpm, standing for 30-35h, orange solid imine bromate was filtered off, washed with butanol, the solid was placed in a 3L reaction vessel, 1.5-1.7L water was added, the solution temperature is raised to 80-85 C, refluxing for 3-3.5 h, zeolite decolorization, filtration, washing the filter cake with p-xylene solution, and the combined filtrate and washings, the temperature of the solution is reduced to 5--9 C, standing for 30-35h, and the precipitated colorless solid was filtered off, dried under low-pressure, got 2,4,6-hydroxyacetophenone. |
