发明名称 |
NEAR INFRARED PHOTOIMMUNOTHERAPY (NIR-PIT) OF SUPPRESSOR CELLS TO TREAT CANCER |
摘要 |
It is shown that CD25-targeted near-infrared photo-immunotherapy causes a unique, rapid and spatially selective depletion of Tregs leading to regression of the treated tumor and inducing systemic immunologic responses in untreated tumors. Based on these observations, provided are compositions and methods of killing immune suppressor cells, for example to treat cancer. Reducing the number of suppressor cells in a subject can remove suppression of effector T cells, for example, to treat cancer using the subject's own immune system. In particular examples, the method includes contacting suppressor cells having a suppressor cell surface protein with an antibody-IR700 molecule, wherein the antibody specifically binds to the suppressor cell surface protein, and in some examples the antibody does not have a functional Fc region. The cell is subsequently irradiated, such as at a wavelength of 660 to 740 nm, for example at a dose of at least 4 J cm-2. |
申请公布号 |
WO2017027247(A1) |
申请公布日期 |
2017.02.16 |
申请号 |
WO2016US45090 |
申请日期 |
2016.08.02 |
申请人 |
THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES |
发明人 |
KOBAYASHI, Hisataka;CHOYKE, Peter;SATO, Kazuhide;SATO, Noriko |
分类号 |
C07K16/28;A61K39/00;A61P35/00 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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