| 发明名称 | Methods and products related to targeted cancer therapy | ||
| 摘要 | The invention relates to methods and related products for treatment and determining modes of treatment for cancer or prognosis of cancer. Preferably the methods are related to the induction of CD80 in p53 responsive cancer cells. | ||
| 申请公布号 | US9567642(B2) | 申请公布日期 | 2017.02.14 |
| 申请号 | US201314376482 | 申请日期 | 2013.02.01 |
| 申请人 | Massachusetts Institute of Technology | 发明人 | Feldser David;Jacks Tyler E.;Schmidt Leah Marie |
| 分类号 | A61K39/395;C12Q1/68;G01N33/574;A61K45/06;C07K16/28 | 主分类号 | A61K39/395 |
| 代理机构 | Wolf, Greenfield & Sacks, P.C. | 代理人 | Wolf, Greenfield & Sacks, P.C. |
| 主权项 | 1. A method, comprising determining the status of p53 in a cancer cell of a subject and administering to the subject an anti-CD80 antibody when the cancer cell has normal p53 or is induced to have p53 activity, such that the cancer cell expresses CD80, wherein the anti-CD80 antibody is conjugated to a toxic compound. | ||
| 地址 | Cambridge MA US | ||