主权项 |
1. A compound represented by general formula (I) below, or a pharmaceutically acceptable salt thereof:wherein
A represents formula (1) below: Q represents CH2 or NH; A1 represents N or CR1; R1 represents a hydrogen atom, C1-3 alkyl group, C1-3 alkoxy group, halogen atom, or cyano group, wherein the C1-3 alkyl group or C1-3 alkoxy group may be substituted with 1 to 5 halogen atoms,wherein when A2 and/or A3 is N, R1 may be an hydrogen atom;
A2 represents N or CR2; R2 represents a hydrogen atom, C1-3 alkyl group, C1-3 alkoxy group, or halogen atom; A3 represents N or CR3; R3 represents a hydrogen atom, C1-6 alkyl group, C1-6 alkoxy group, or halogen atom; R4 represents a C1-6 alkylsulfonyl group, C1-6 alkylsulfanyl group, C1-6 alkylsulfinyl group, C3-8 cycloalkylsulfonyl group, C3-8 cycloalkylsulfanyl group, C3-8 cycloalkylsulfinyl group, C6-10 arylsulfonyl group, C6-10 arylsulfanyl group, or C6-10 arylsulfinyl group; R5 represents a halogen atom, C1-6 alkyl group, C1-6 alkoxy group, C2-6 alkenyl group, cyano group, nitro group, C3-8 cycloalkyl group, 4- to 10-membered aromatic ring, 4- to 10-membered aromatic heterocycle, 3- to 12-membered heterocycle, or C1-6 alkylsulfanyl group, wherein the C1-6 alkyl group, C1-6 alkoxy group, C2-6 alkenyl group, or C1-6 alkylsulfanyl group may be substituted with 1 to 5 halogen atoms; R6 represents a hydrogen atom, a C1-6 alkyl group, C2-6 alkenyl group, halogen atom, formyl group, [1,3]dioxolane, or a group represented by formula (i) below, wherein the C1-6 alkyl group or C2-6 alkenyl group may be substituted with 1 to 5 amino, hydroxyl, and/or OSO2CH3 groups,
●-X—Y—Z (i)wherein in formula (i),
X represents —(CH2)n—, —NH—, or —O—; Y represents a 4- to 10-membered aromatic ring, 3- to 12-membered heterocycle, or 4- to 10-membered aromatic heterocycle, wherein the 4- to 10-membered aromatic ring, 3- to 12-membered heterocycle, and 4- to 10-membered aromatic heterocycle may be substituted with 1 to 5 halogen atoms and/or C1-3 alkyl groups; Z represents a hydrogen atom, a C1-6 alkyl group, a C2-6 alkynyl group, a C3-8 cycloalkyl group, —(CH2)mNRaRb, —NHCO(CH2)mRc, —(CH2)mNHCORc, —NH(CH2)mCORc, —(CH2)mN(CH3)CORc, —(CH2)mORd, —(CH2)mCORe, —(CH2)mCOORe, —(CH2)mNHSO2Rf, —(CH2)mSO2Rf, —(CH2)mCONRgRh, a 4- to 10-membered aromatic ring, 4- to 10-membered aromatic heterocycle, or a 3- to 12-membered heterocycle, wherein the C1-6 alkyl group may be substituted with 1 to 5 halogen atoms, hydroxyl groups, and/or cyano groups; and the 3- to 12-membered heterocycle and 4- to 10-membered aromatic heterocycle may be substituted with 1 to 5 halogen atoms, C1-3 alkyl groups, and/or oxo groups; n represents 0, 1, 2, or 3; m represents 0, 1, 2, or 3; Ra and Rb are identical or different, each representing a hydrogen atom, C1-6 alkyl group, C2-6 alkynyl group, 3- to 12-membered heterocycle, 4- to 10-membered aromatic heterocycle, or —SO2CH3, wherein the C1-6 alkyl group may be substituted with 1 to 5 halogen atoms, amino groups, mono-C1-6 alkylamino groups, di-C1-6 alkylamino groups, hydroxyl groups, and/or cyano groups; Rc represents a C1-6 alkyl group, C1-6 alkoxy group, C3-8 cycloalkyl group, amino group, or 3- to 12-membered heterocycle, wherein the C1-6 alkyl group may be substituted with 1 to 3 amino groups, mono-C1-6 alkylamino groups, di-C1-6 alkylamino groups, and/or 3- to 12-membered heterocycles; Rd represents a hydrogen atom, C1-6 alkyl group, C2-3 alkenyl group, or C2-6 alkynyl group, wherein the C1-6 alkyl group may be substituted with 1 to 5 C1-6 alkoxy groups and/or amino groups; Re represents a hydrogen atom or C1-6 alkyl group, wherein the C1-6 alkyl group may be substituted with an amino group; Rf represents a C1-6 alkyl group, an amino group, a mono-C1-6 alkylamino group, or a di-C1-6 alkylamino group; and Rg and Rh are identical or different, each representing a hydrogen atom, C1-6 alkyl group, or 3- to 12-membered heterocycle, wherein the C1-6 alkyl group may be substituted with 1 to 3 amino groups, mono-C1-6 alkylamino groups, and/or di-C1-6 alkylamino groups; and R7 represents a hydrogen atom, halogen atom, C1-6 alkyl group, C2-6 alkenyl group, C1-6 alkoxy group, cyano group, or a group represented by formula (ii) below, wherein the C1-6 alkyl group may be substituted with 1 to 5 halogen atoms:
●-X2—Y2—Z2 (ii)wherein X2 represents —(CH2)p—;
Y2 represents a 3- to 12-membered heterocycle or 4- to 10-membered aromatic heterocycle; Z2 represents a hydrogen atom, C1-6 alkyl group, C2-6 alkenyl group, C1-6 alkoxy group, C3-7 cycloalkyl group, cyano group, or COORi; p represents 0, 1, or 2; and Ri represents a C1-6 alkyl group. |