主权项 |
1. A composition comprising a pharmaceutical agent, wherein the pharmaceutical agent has a solubility of 33 mg/mL to less than 0.1 mg/mL in an aqueous solvent, wherein the pharmaceutical agent is non-covalently complexed to a compound having the following structure: or a salt, a partial salt, a hydrate, or a stereoisomer thereof, wherein each R is independently hydrogen, C1 to C20 alkyl group, C3 to C20 carbocyclic group, C1 to C20 heterocyclic group, carboxylic acid group, ester group, amide group, hydroxy, or ether group; wherein, optionally, adjacent R groups form a C3 to C20 carbocyclic ring or heterocyclic ring; wherein eachis independently a C5 to C20 carbocyclic ring system or C2 to C20 heterocyclic ring system, wherein the ring system comprises one or more rings;
wherein at least one ring system has at least one solubilizing group selected from sulfonic acid group, sulfonate salt group, phosphonic acid group, phosphonate salt group, and polyethylene glycol group; wherein, optionally, the ring system has a targeting group; wherein n is 1 to 5. |