Peptidyl arginine deiminase 1 and/or 3 activator compounds in the epidermis and uses thereof

摘要

The present invention relates to the activation of peptidyl arginine deiminase (PADs) 1 and/or 3 in the epidermis by at least one active agent used alone or in combination, namely caffeine, acefylline and/or theobromine in a cosmetic and/or pharmaceutical composition. The present invention also relates to the use of the aforementioned active agents in cosmetics and/or therapeutics, alone or in combination, in order to improve the barrier functions of the epidermis, to prevent and/or treat symptoms related to dry skin or to improve and/or promote hydration of the keratinous layer. Finally, the invention relates to increasing the activity of PAD1 and/or PAD3 in the epidermis.

主权项

1. A method to treat an individual in need of skin moisturization comprising:
administering to the individual an effective amount of a composition including acefylline or a salt thereof to moisturize the skin, wherein the composition further comprises at least one liquid fatty phase including at least one compound selected from oils and/or solvents of mineral, animal, vegetable or synthetic origin, containing carbon, hydrocarbon, fluorine and/or silicone, volatile or non-volatile, alone or in mixture.