| 摘要 |
The present invention relates to a compound of formula (I) wherein: —i is 0 or 1; j is 0 or 1; k is 0 or 1; —R1 and R2 are in particular H, (C1-C12)alkyl, or a group of formula C(O)R; —R is a, linear or branched, alkyl radical, comprising at least 19 carbon atoms; —R3 is H and k=0 when j=1; or, when j=0, R3 is —C(O)R or -L-C(O)R; —L, U and L″ are linkers; wherein, when j=0, at least one of the groups R1; R2 and R3 comprises a radical R.; |
| 主权项 |
1. A compound of formula (I): wherein:
i is 0 or 1;j is 0 or 1;k is 0 or 1;R1 is chosen from the group consisting of: H, (C1-C12)alkyl, (C3-C6)cycloalkyl, and (C6-C10)aryl radicals; or R1 may form a heterocycloalkyl radical with the oxygen atom bearing it; or R1 is a group of formula C(O)R, R being as defined below;R2 is chosen from the group consisting of: H, (C1-C12)alkyl, (C3-C6)cycloalkyl, and (C6-C10)aryl radicals; or R2 may form a heterocycloalkyl radical with the oxygen atom bearing it; or R2 is a group of formula C(O)R, R being as defined below;R is a, linear or branched, alkyl radical, possibly interrupted by one or several double bonds, comprising at least 19 carbon atoms, and wherein one or several hydrogen atoms may be replaced by deuterium atoms;R3 is H and k=0 when j=1; or, when j=0, R3 is a group of formula —C(O)R or -L-C(O)R, R being as defined above;L is a linker having one of the following formulae (L1) or(L2) wherein:
A1 is an alkylene radical comprising from 3 to 6 carbon atoms;A′1 is an alkylene radical comprising from 1 to 6 carbon atoms, optionally interrupted by one or several heteroatoms, such as oxygen atoms;X1 is a radical —C(O)— or an alkylene radical comprising from 1 to 6 carbon atoms;X2 is a radical —C(O)— or an alkylene radical comprising from 1 to 6 carbon atoms;X′1 is chosen from the group consisting of: —O—, —N(Ra)— or an alkylene radical comprising from 1 to 6 carbon atoms, optionally interrupted by one or several heteroatoms, such as oxygen atoms, Ra being H or an alkyl group comprising from 1 to 6 carbon atoms;L′ is a linker of formula -(A)p-(X)q—C(O)—, wherein:
p is 0 or 1;q is 0 or 1;A is an alkylene radical comprising from 1 to 6 carbon atoms, optionally interrupted by one or several heteroatoms, such as oxygen atoms,X is —O—, —N(Rb)— or an alkylene radical comprising from 1 to 6 carbon atoms, Rb being H or an alkyl group comprising from 1 to 6 carbon atoms;L″ is a linker chosen from the group consisting of: (C6-C10)arylene, (C1-C12)alkylene, (C1-C12)alkylene-(C6-C10)arylene, (C6-C10)arylene-(C1-C12)alkylene, —CH═CH—(C6-C10)arylene and (C1-C12)alkylene-CH═CH—(C6-C10)arylene radicals;wherein, when j=0, at least one of the groups R1, R2 and R3 comprises a radical R; provided that the compound of formula (I) is other than the following compound:or its pharmaceutically acceptable salts, racemates, diastereomers or enantiomers. |
