| 主权项 |
1. A method to effect antibiotic activity which method comprises contacting bacteria with a compound of formula (I) wherein S1, S2, S3, S4 are independently H, F, Cl, Br, I, hydroxy-, thiol-, thioether, NH2, nitro-, cyano-, isocyano-, carboxylic acid, alkyl-, hydroxyalkyl-, alkoxy-, alkoxyalkyl-, a carbocyclic- or a heterocyclic group, orwherein S5-S9 is independently H or F;
wherein Y1 and Y2 are selected from the group consisting of CH, CF, C-alkyl, C-alkoxy, C-alkoxyalkyl, C-carbocycle, C-heterocycle or N; n, m are independently 0-8; Pn1, Pn2, Qm1, Qm2 are independently H, halogen, alkyl, alkoxy, alkoxyalkyl, carbocycle or heterocycle; wherein if n=0 or 1, then X1 is H, OX3, wherein if m=0 or 1, then X2 is H, OX3,and
wherein if n is 2-8, then X1=OX3,and
wherein if m=2-8, then X2=OX3, wherein one of Y3, Y4 and Y5 is C or N, and the others of Y3, Y4 and Y5 are C, and that if Yn═N, the R-group on that N-atom is void; wherein R1-R5 are independently H, OH, alkyl, alkoxy, alkoxyalkyl, carbocycle or heterocycle; wherein X3=H, alkyl or (—CO)—R6, wherein R6=alkyl; and wherein R7-R20 are independently H, F, Cl, Br, I, hydroxy-, thiol-, thioether, NH2, nitro-, cyano-, isocyano-, carboxylic acid, alkyl-, hydroxyalkyl-, alkoxy-, alkoxyalkyl-, a carbocyclic- or a heterocyclic group; or a pharmaceutically acceptable salt thereof. |
