| 主权项 |
1. A MMethod for preparing an osteoconductive bone paste, comprising at least the following steps:
(a) a providing step during which an initial mixture is supplied, in a container, including an aqueous solution and a granular product comprising at least collagen and minerals, the collagen representing between 30 and 90% of the granular product by dry weight and the minerals representing between 10 and 70% of the granular product by dry weight, at least a portion of the collagen being contained in particles of at least partially mineralized bone matrix, (b) a heating step during which the initial mixture is heated in the container, at a temperature of at least 100° C., to transform a portion of the collagen into gelatin so that there is continuity between the gelatin and the at least partially mineralized bone matrix and a cohesive bone paste is thus obtained of defined viscosity, the heating step enabling sterilization of the bone paste in the container. the bone paste being kept in the container, so that after cooling and gelling, the bone paste is ready for use and remains sterile in said container, the container being in a closed and fluidtight state. |
