发明名称 |
AN ISOLATED DONOR MHC-DERIVED PEPTIDE AND USES THEREOF |
摘要 |
The invention relates to an peptide derived from a polymorphic region of donor MHC class II molecules which induces tolerance and thus prevents transplant rejection in a patient in need thereof. The invention relates to an isolated peptide of 15 or 16 amino acids long that comprises or consists of the amino acid sequence: REEYARFDSDVGEYR (SEQ ID NO: 1) or a function-conservative variant for use as drug. The invention relates to an in vitro method for determining whether a transplanted patient is tolerant, comprising a step of determining the presence of CD8+CD45RClow Tregs in a biological sample obtained from said transplanted patient, wherein the presence of CD8+CD45RClow Tregs is indicative of tolerance. |
申请公布号 |
EP3126377(A1) |
申请公布日期 |
2017.02.08 |
申请号 |
EP20150713503 |
申请日期 |
2015.04.01 |
申请人 |
INSERM (Institut National de la Santé et de la Recherche Médicale);Universite de Nantes |
发明人 |
GUILLONNEAU, Carole;ANEGON, Ignacio;PICARDA, Elodie |
分类号 |
C07K14/435 |
主分类号 |
C07K14/435 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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