| 主权项 |
1. A compound represented by formula (I): or a pharmaceutically acceptable salt thereof, wherein: X1, X2, and X3 are CH; or one of X1, X2, or X3 is N and the other two are CH; R1 is R2 is a C1-4haloalkyl or cyano; R3 is -L1-J-L2-R12; and R4 is hydrogen or a C1-6alkyl; or R3 and R4 together with the nitrogen to which they are attached are a 3- to 8-membered heterocyclyl which is substituted with -L2-R12, and is optionally substituted with a halo, hydroxyl, amino, or a C1-6alkyl; R5 is a halo, a C1-6alkyl or a C1-6haloalkyl; R6 and R7 are each independently hydrogen or C1-6alkyl; or R6 and R7 together with the carbon to which they are attached are —C(═O)—, a C3-8spirocycloalkyl, or a 3- to 8-membered spiroheterocyclalkyl; R8 and R9 are each independently hydrogen or a C1-6alkyl; or R8 and R9 taken together with the carbon to which they are attached are —C(═O)—; R10, for each occurrence, is halo; R11 is hydrogen, halo, or C1-4alkyl; R12 is —COOR13 or —P(O)(OR13)2; each R13, independently, is H, C1-4alkyl, aryl, or aryl-C1-4-alkyl; J is a C1-6alkylene, a C3-8cycloalkylene, a 3- to 8-membered divalent monocyclic heterocyclyl, a phenylene, or a 5- to 6-membered heteroarylene, wherein J is optionally substituted with one or two substituents independently selected from a halo and a C1-6alkyl; L1 and L2 are each independently, a C1-3alkylene or a direct bond; n is 1, 2 or 3; q is 1 or 2; and r is 0, 1, or 2. |
