Peptide inhibitors of nicotinic acetylcholine receptor

摘要

The present invention refers to biochemistry, namely to new peptide compounds having the ability to selectively block the muscle-type nicotinic acetylcholine receptor. The claimed compounds have common formula (I): X1-X2-X3-Pro-X4-Pro-X5 (SEQ ID NO: 54), where X1 is chosen within H, Ac—, Palm-; X2 is chosen within Trp, Tyr; X3 is chosen within Trp, Tyr; X4 is chosen within Lys, Orn, Dbu, Dpr, Arg; X5 is chosen within —OH, —NH2, —OCH3, —OC2H5, —NH—C6H5. The invention can be applied in cosmetics for smoothing mimic and age-related Wrinkles.

主权项

1. A cosmetic composition for smoothing facial and age-related wrinkles, comprising a compound of the general formula (I): X1-X2-X2-Pro-X4-Pro-X5 (SEQ ID NO:54), wherein:
X1 is selected from the group consisting of H—, Ac—, and Palm-; X2 is selected from the group consisting of Trp, and Tyr; X3 is selected from the group consisting of Trp, and Tyr; X4 is selected from the group consisting of Lys, Orn, Dbu, Dpr, and Arg; and X5 is selected from the group consisting of —OH, —NH2, —OCH3, —OC2H5, and —NHC6H5; or a cosmetically acceptable retro-isomer and/or salt thereof; wherein the compound is present in an amount effective to selectively block muscle-type nicotinic acetylcholine receptors and suitable for smoothing facial and age-related wrinkles; and wherein the cosmetic composition is in the form of a lotion, balm, cream, gel, gel forming polymers, spray, or face mask.