| 主权项 |
1. A method of detecting an amyloid peptide, the method comprising:
(i) contacting an amyloid peptide with a compound having the structure of formula (I), or a pharmaceutical acceptable salt thereof, thereby forming a detectable amyloid complex; and (ii) detecting said detectable amyloid complex; wherein formula (I) has the structure: wherein
EDG is an electron donor group;πCE is a pi-conjugation element; andWSG is a water soluble group; wherein
said EDG is R1-substituted or unsubstituted alkyl, R1-substituted or unsubstituted cycloalkyl, R1-substituted or unsubstituted heteroalkyl, R1-substituted or unsubstituted heterocycloalkyl, R1-substituted or unsubstituted aryl, R1-substituted or unsubstituted heteroaryl, —OR2NR4C(O)R3, —NR4R5, —SR6, or —PR7R8, wherein
R1 is halogen, —OR9, —NR10R11, unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl;R2, R3, R4, R5, R6, R7 and R8 are independently hydrogen, R12-substituted or unsubstituted alkyl, R12-substituted or unsubstituted heteroalkyl, R12-substituted or unsubstituted cycloalkyl, R12-substituted or unsubstituted heterocycloalkyl, R12-substituted or unsubstituted aryl or R12-substituted or unsubstituted heteroaryl, wherein R4 and R5 are optionally joined together to form an R12-substituted or unsubstituted heterocycloalkyl, or R12-substituted or unsubstituted heteroaryl;R9, R10 and are independently hydrogen, R12-substituted or unsubstituted alkyl, R12-substituted or unsubstituted heteroalkyl, R12-substituted or unsubstituted cycloalkyl, R12-substituted or unsubstituted heterocycloalkyl, R12-substituted or unsubstituted aryl, or R12-substituted or unsubstituted heteroaryl, wherein R10 and are optionally joined together to form an R12-substituted or unsubstituted heterocycloalkyl, or R12-substituted or unsubstituted heteroaryl;R12 is halogen, —OR13, —NR14R15, R16-substituted or unsubstituted alkyl, R16-substituted or unsubstituted heteroalkyl, R16-substituted or unsubstituted cycloalkyl, R16-substituted or unsubstituted heterocycloalkyl, R16-substituted or unsubstituted aryl, or R16-substituted or unsubstituted heteroaryl;R13, R14 and R15 are independently hydrogen or unsubstituted alkyl; andR16 is unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl; wherein
said pi-conjugation element has the formula:
-L1-(A1)q-L2-(A2)r-L3- or -L1-(A1)q-L4-A3-L2-(A2)r-L3-, wherein
q and r are independently 0 or 1, wherein at least one of q or r is 1;A1, A2 and A3 are independently R17-substituted or unsubstituted arylene or R17-substituted or unsubstituted heteroarylene;L1, L2, L3 and L4 are independently a bond or a linking group having the formula: wherein x is an integer from 1 to 50;
R17 is halogen, —OR18—NR19R20, R21-substituted or unsubstituted alkyl, R21-substituted or unsubstituted heteroalkyl, R21-substituted or unsubstituted cycloalkyl, R21-substituted or unsubstituted heterocycloalkyl, R21-substituted or unsubstituted aryl, or R21-substituted or unsubstituted heteroaryl;R18, R19 and R20 are independently hydrogen, R21-substituted or unsubstituted alkyl, R21-substituted or unsubstituted heteroalkyl, R21-substituted or unsubstituted cycloalkyl, R21-substituted or unsubstituted heterocycloalkyl, R21-substituted or unsubstituted aryl, or R21-substituted or unsubstituted heteroaryl;R21 is halogen, —OR22, —NR23R24, unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl;R22, R23 and R24 are independently hydrogen or unsubstituted alkyl; and wherein
said water soluble group is R25-substituted or unsubstituted alkyl, R25-substituted or unsubstituted heteroalkyl, R25-substituted or unsubstituted cycloalkyl, R25-substituted or unsubstituted heterocycloalkyl, R25-substituted or unsubstituted aryl, R25-substituted or unsubstituted heteroaryl; wherein
R25 is halogen, —OR26, —NR27R28, R29-substituted or unsubstituted alkyl, R29-substituted or unsubstituted heteroalkyl, R29-substituted or unsubstituted cycloalkyl, R29-substituted or unsubstituted heterocycloalkyl, R29-substituted or unsubstituted aryl, or R29-substituted or unsubstituted heteroaryl;R26, R27 and R28 are independently hydrogen, R29-substituted or unsubstituted alkyl, R29-substituted or unsubstituted heteroalkyl, R29-substituted or unsubstituted cycloalkyl, R29-substituted or unsubstituted heterocycloalkyl, R29-substituted or unsubstituted aryl, or R29-substituted or unsubstituted heteroaryl, wherein R27 and R28 are optionally joined together to form an R29-substituted or unsubstituted heterocycloalkyl, or R29-substituted or unsubstituted heteroaryl;R29 is halogen, —OR30, —NR31R32, unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, or unsubstituted heteroaryl; andR30, R31 and R32 are independently hydrogen or unsubstituted alkyl. |
