发明名称 |
MULTIMERISKE TIE 2-AGONISTER OG ANVENDELSER DERAF VED STIMULERING AF ANGIOGENESE |
摘要 |
The present invention provides a multimeric form of a Tie 2 binding peptide monomer, wherein the multimeric form has Tie 2 agonist activity. The multimeric form, preferably a tetramer, stimulates angiogenesis and promotes wound healing. The present invention also features pharmaceutical compositions comprising the multimeric Tie 2 agonists, including those suitable for topical or systemic administration. Methods of using the multimeric Tie 2 agonists of the invention for stimulating angiogenesis and for promoting healing of wounds, such as diabetic ulcers or skin grafts, are also provided. |
申请公布号 |
DK2076290(T3) |
申请公布日期 |
2017.01.23 |
申请号 |
DK20070816053T |
申请日期 |
2007.10.26 |
申请人 |
Sunnybrook Health Sciences Center |
发明人 |
VAN SLYKE, Paul;DUMONT, Daniel |
分类号 |
A61K38/17;A61K38/18;A61L27/60;A61P9/00;A61P17/02;A61P39/00;C12Q1/48;G01N33/577;G01N33/94 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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