| 发明名称 |
HYBRID POLYKETIDE SYNTHASES |
| 摘要 |
The present invention provides for a polyketide synthase (PKS) capable of synthesizing an even-chain or odd-chain diacid or lactam or diamine. The present invention also provides for a host cell comprising the PKS and when cultured produces the even-chain diacid, odd-chain diacid, or KAPA. The present invention also provides for a host cell comprising the PKS capable of synthesizing a pimelic acid or KAPA, and when cultured produces biotin. |
| 申请公布号 |
US2017015990(A1) |
申请公布日期 |
2017.01.19 |
| 申请号 |
US201615144727 |
申请日期 |
2016.05.02 |
| 申请人 |
The Regents of the University of California |
发明人 |
Fortman Jeffrey L.;Hagen Andrew;Katz Leonard;Keasling Jay D.;Poust Sean;Zhang Jingwei;Zotchev Sergey |
| 分类号 |
C12N9/00;C12P13/00;C12P7/46;C12P17/10;C12P17/18;C12P7/44 |
主分类号 |
C12N9/00 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A non-naturally occurring polyketide synthase (PKS) which synthesizes an even-chain diacid, wherein the PKS is a hybrid PKS comprising domains from two or more PKSs. |
| 地址 |
Oakland CA US |
