| 摘要 |
The disclosure relates to Compounds of Formula (1) :;
and pharmaceutically acceptable salts thereof wherein Z1, Z2, Z3, Xa, Xb, Xc, Y, X2, and X4 are as defined herein, compositions comprising an effective amount of a Compound of Formula (1) or a pharmaceutically acceptable salt thereof, and methods to treat or prevent a condition, such as cancer which overexpresses Her-kinases, comprising administering to an patient in need thereof a therapeutically effective amount of a Compound of Formula (1) or a pharmaceutically acceptable salt thereof. |
| 主权项 |
1. A compound of Formula (1):or a pharmaceutically acceptable salt thereof, wherein:
(a) each of Z1, Z2 and Z3 is independently CH or N; (b) Y is S; (c) Xa and Xb are O; (d) Xc is —CH2—; (e) X2 is —NR1R2, wherein R1 and R2 are each independently H, C1-6 alkyl, C2-C6 alkenyl, C2-6 alkenyl, cycloalkyl, heteroalkyl, heterocycloalkyl, aryl, heteroaryl, alkylaryl, arylalkyl, alkylheteroaryl, heteroarylalkyl, or alkylheteroarylalkyl; (f) X4 is hydrogen or halogen; (g) R is —R10—NH—R11 wherein R10 is ethylene or propylene, and
(i) R11 is isopropyl or t-butyl, or(ii) R11 is a branched alkyl, Z1, Z2 and Z3 are each N, and R1 and R2 are each independently alkyl which has 1, 3, 4, 5, or 6 carbon atoms, C2-C6 alkenyl, C2-6 alkynyl, cycloalkyl, heteroalkyl, heterocycloalkyl, aryl, heteroaryl, alkylaryl, arylalkyl, alkylheteroaryl, heteroarylalkyl, or alkylheteroarylalkyl. |
