发明名称 |
SELECTIVE ANTISENSE COMPOUNDS AND USES THEREOF |
摘要 |
The present invention provides gapped oligomeric compounds. More particularly the gapped oligomeric compounds provided herein comprise at least one modified intemucleoside linkage in the gap region. Such gapped oligomeric compounds have one or more improved properties such as selectivity, potency, improved toxicity profile and or improved proinflammatory profile. Certain such oligomeric compounds are useful for hybridizing to a complementary nucleic acid, including but not limited, to nucleic acids in a cell. In certain embodiments, hybridization results in modulation of the amount activity or expression of the target nucleic acid in a cell. |
申请公布号 |
EP2742056(B1) |
申请公布日期 |
2017.01.11 |
申请号 |
EP20120822510 |
申请日期 |
2012.08.08 |
申请人 |
Ionis Pharmaceuticals, Inc. |
发明人 |
SETH, Punit, P.;OESTERGAARD, Michael;SWAYZE, Eric, E. |
分类号 |
C12N15/113;A61K31/7088;C12N15/11 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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